BDBM402780 2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct-2- yl]-N-[2- (trifluoromethyl)thiophen- 3-yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 87

SMILES FC(F)(F)c1sccc1NC(=O)c1ccc2cnc(nn12)N1C[C@H]2CC[C@@H]1CN2

InChI Key InChIKey=BELKBRCCXCFUPE-GHMZBOCLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402780   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402780(2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct...)
Affinity DataIC50:  1.44E+3nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent