BDBM402782 2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}- N-(3-bromo-1-methyl- 1H-pyrazol-4- yl)pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 89

SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@@H]4CCCC(F)(F)[C@@H]4N)nn23)c(Br)n1

InChI Key InChIKey=AWPFBQFOVUDWNE-ZWNOBZJWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402782   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402782(2-{[(1R,2R)-2-amino-3,3- difluorocyclohexyl]amino}...)
Affinity DataIC50:  373nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent