BDBM402849 2-{[(3R,5R)-5- fluoropiperidin-3- yl]amino}-N-[1-methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 162

SMILES Cn1cc(NC(=O)c2ccc3cnc(N[C@H]4CNC[C@H](F)C4)nn23)c(n1)C(F)(F)F

InChI Key InChIKey=FYKGOHCPLXRQIX-NXEZZACHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402849   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402849(2-{[(3R,5R)-5- fluoropiperidin-3- yl]amino}-N-[1-m...)
Affinity DataIC50:  18nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent