BDBM404331 1-[2-({(2R,5R)-5-[5-(1-Hydroxy-1- methylethyl)isothiazol-3-yl]-2- methylpiperidin-1-yl} carbonyl)phenyl]cyclopropanecarbonitrile::US10017504, 62

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1cc(sn1)C(C)(C)O

InChI Key InChIKey=BOLIVFQLBGTMBL-HZPDHXFCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404331   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404331(1-[2-({(2R,5R)-5-[5-(1-Hydroxy-1- methylethyl)isot...)
Affinity DataIC50: >1.00E+4nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404331(1-[2-({(2R,5R)-5-[5-(1-Hydroxy-1- methylethyl)isot...)
Affinity DataIC50:  19.1nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent