BDBM404337 2-{3-[(3R,6R)-6-Methyl-1-{[2- (trifluoromethoxy)phenyl] carbonyl}piperidin-3-yl] isothiazol-5-yl}propan-2-ol::US10017504, 68

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cccnc1OCC(F)(F)F)c1cc(sn1)C(C)(C)O

InChI Key InChIKey=ILESPBYNBQEYIU-CHWSQXEVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 404337   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404337(2-{3-[(3R,6R)-6-Methyl-1-{[2- (trifluoromethoxy)ph...)
Affinity DataIC50: >1.00E+4nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM404337(2-{3-[(3R,6R)-6-Methyl-1-{[2- (trifluoromethoxy)ph...)
Affinity DataIC50:  22.8nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent