BDBM406171 1-(trans-2-hydroxy- 1,2,3,4- tetrahydronaphthalen-1- yl)-3-(3-(2- methoxypyrimidin-5-yl)- 4-methyl-1-phenyl-1H- pyrazol-5-yl)urea::US10351575, Example 119::US10889589, EX. # 119

SMILES COc1ncc(cn1)-c1nn(c(NC(=O)NC2[C@H](O)CCc3ccccc23)c1C)-c1ccccc1

InChI Key InChIKey=IUSIIRDIRUIPHW-FKHAVUOCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406171   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM406171(1-(trans-2-hydroxy- 1,2,3,4- tetrahydronaphthalen-...)
Affinity DataIC50: <100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM406171(1-(trans-2-hydroxy- 1,2,3,4- tetrahydronaphthalen-...)
Affinity DataIC50: <100nMAssay Description:TrkA binding activity was determined in a TrkA LanthaScreen™ Eu Kinase Binding Assay. 5 nM His-tagged recombinant human TrkA (6HIS tagged cytoplasmic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent