BDBM406834 N-{4-[(5-{[(2-hydroxy-2-methylpropyl)amino]methyl}-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]pyridin-2-yl}acetamide::US10336761, Example 117

SMILES CC(=O)Nc1cc(Nc2nc(nn3ccc(CNCC(C)(C)O)c23)-c2ccccn2)ccn1

InChI Key InChIKey=WIBYDWSNIHNEPL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406834   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406834(N-{4-[(5-{[(2-hydroxy-2-methylpropyl)amino]methyl}...)
Affinity DataIC50:  340nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406834(N-{4-[(5-{[(2-hydroxy-2-methylpropyl)amino]methyl}...)
Affinity DataIC50:  0.850nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent