BDBM406991 3-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl}methyl)piperazin-1-yl]phenol::US10336761, Example 275

SMILES Oc1cccc(c1)N1CCN(Cc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)CC1

InChI Key InChIKey=MOIOXFPYLVZEQP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406991   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406991(3-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-...)
Affinity DataIC50:  3.60E+3nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406991(3-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-...)
Affinity DataIC50:  0.470nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent