BDBM407046 2-[(2-hydroxy-2-methylpropyl)amino]-N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)pyridin-2-yl]acetamide::US10336761, Example 330

SMILES CC(C)(O)CNCC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)(F)F)ccn1

InChI Key InChIKey=WWLICFYQSOHLEQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407046   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM407046(2-[(2-hydroxy-2-methylpropyl)amino]-N-[4-({2-[6-(t...)
Affinity DataIC50: >1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM407046(2-[(2-hydroxy-2-methylpropyl)amino]-N-[4-({2-[6-(t...)
Affinity DataIC50:  0.600nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent