BDBM407752 6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-((R)- 2-fluoro-3-hydroxy-3- methylbutyl)-4-(((1r,3R)-3- (((5-methyl-1,3,4-oxadiazol- 2-yl)amino)methyl)cyclo- butyl)amino)nicotinamide::US10336762, Compound 694

SMILES Cc1nnc(NC[C@H]2C[C@@H](C2)Nc2cc(ncc2C(=O)NC[C@@H](F)C(C)(C)O)-c2ccc3cc(cnn23)C#N)o1

InChI Key InChIKey=UTKVEQBKEGOJME-BUKPSGGLSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407752   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407752(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-((R)- 2...)
Affinity DataIC50: <1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407752(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-((R)- 2...)
Affinity DataEC50:  102nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent