BDBM407808 (R)-methyl 3-((2-(3-cyano- pyrrolo[1,2-b]pyridazin-7- yl)-5-(((R)-2-fluoro-3- hydroxy-3-methylbutyl) carbamoyl)pyridin-4- yl)amino)pyrrolidine-1- carboxylate::US10336762, Compound 752

SMILES COC(=O)N1CC[C@H](C1)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=GUJSUURNRWCKEQ-OPAMFIHVSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407808   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407808((R)-methyl 3-((2-(3-cyano- pyrrolo[1,2-b]pyridazin...)
Affinity DataIC50: <1nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407808((R)-methyl 3-((2-(3-cyano- pyrrolo[1,2-b]pyridazin...)
Affinity DataEC50:  80nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent