BDBM408383 US10357493, Example 100(+)

SMILES C[C@H](Nc1ncc(cn1)-c1nnc(o1)C(F)F)c1c(F)cccc1F

InChI Key InChIKey=KRUCSAOKYMGRKK-ZETCQYMHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408383   

TargetHistone deacetylase 1(Homo sapiens (Human))
Selenity Therapeutics (Bermuda)

US Patent
LigandPNGBDBM408383(US10357493, Example 100(+))
Affinity DataIC50: >3.00E+4nMAssay Description:All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Selenity Therapeutics (Bermuda)

US Patent
LigandPNGBDBM408383(US10357493, Example 100(+))
Affinity DataIC50:  30nMAssay Description:All enzymatic reactions were conducted in duplicate at room temperature for 17 hours in a 50 μl mixture containing HDAC assay buffer (50 mM Tris...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent