BDBM408547 (R)- or (S)-6-(5-(1-(2- fluoro-4-(trifluoromethyl)- phenyl)ethyl)-4-methyl-4H- 1,2,4-triazol-3-yl)-2- methylpyrimidin-4(3H)-one::US10358435, Example 63::US10358435, Example 64

SMILES CC(c1nnc(-c2cc(=O)[nH]c(C)n2)n1C)c1ccc(cc1F)C(F)(F)F

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408547   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408547((R)- or (S)-6-(5-(1-(2- fluoro-4-(trifluoromethyl)...)
Affinity DataKi:  16nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408547((R)- or (S)-6-(5-(1-(2- fluoro-4-(trifluoromethyl)...)
Affinity DataKi:  23.3nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent