BDBM408575 (S)- or (R)-6-(7-(2-Fluoro-4- (trifluoromethyl)phenyl)-7- methyl-4,5,6,7-tetrahydro- [1,2,3]triazolo[1,5-a]pyridin-3- yl)-2-(3-methoxy- benzyl)pyrimidin-4(3H)-one::US10358435, Example 91::US10358435, Example 92

SMILES COc1cccc(Cc2nc(cc(=O)[nH]2)-c2nnn3c2CCCC3(C)c2ccc(cc2F)C(F)(F)F)c1

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408575   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408575((S)- or (R)-6-(7-(2-Fluoro-4- (trifluoromethyl)phe...)
Affinity DataKi:  0.560nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408575((S)- or (R)-6-(7-(2-Fluoro-4- (trifluoromethyl)phe...)
Affinity DataKi:  728nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent