BDBM409971 2-Amino-8-(3-anilinoazetidine-1-carbonyl)-N,N-dipropyl-3H-1-benzazepine-4-carboxamide::US10370338, Example 3

SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)N1CC(C1)Nc1ccccc1

InChI Key InChIKey=SMZHZZOAKXMXRH-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 409971   

TargetToll-like receptor 7(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM409971(2-Amino-8-(3-anilinoazetidine-1-carbonyl)-N,N-dipr...)
Affinity DataEC50:  2.40E+4nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetToll-like receptor 8(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM409971(2-Amino-8-(3-anilinoazetidine-1-carbonyl)-N,N-dipr...)
Affinity DataEC50:  5nMAssay Description:For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent