BDBM410035 US10370339, Example 2-42
SMILES CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1
InChI Key InChIKey=ZZTIQCGBQGBOBW-WMVAVLGLSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 410035
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 12nMAssay Description:Mutant IDH1 R132H Biochemical Assay mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (a-KG) to (2R)-2-hydroxyglutarate (2-HG). NA...More data for this Ligand-Target Pair