BDBM410187 6-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoropyridin-3-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile ::US10370379, Compound 4::US11059827, Compound 4

SMILES F[C@H]1C[C@@H](N(C1)c1nc2c(cnn2cc1F)C#N)c1cncc(F)c1

InChI Key InChIKey=UVWMNONKVVQRFQ-GXTWGEPZSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 410187   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM410187(6-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoropyridin-3-...)
Affinity DataIC50: <100nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM410187(6-fluoro-5-((2R,4S)-4-fluoro-2-(5-fluoropyridin-3-...)
Affinity DataIC50: <10nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent