BDBM410188 5-((2R,4S)-4-cyano-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile ::US10370379, Compound 5::US11059827, Compound 5

SMILES Fc1ccc(F)c(c1)[C@H]1C[C@@H](CN1c1ccn2ncc(C#N)c2n1)C#N

InChI Key InChIKey=GUHRRWWDOFQWKH-BDJLRTHQSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 410188   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM410188(5-((2R,4S)-4-cyano-2-(2,5-difluorophenyl)pyrrolidi...)
Affinity DataIC50:  300nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM410188(5-((2R,4S)-4-cyano-2-(2,5-difluorophenyl)pyrrolidi...)
Affinity DataIC50:  55nMAssay Description:In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent