BDBM411429 US10392376, Example 3::US10800769, Example 3::US11434233, Example 3::diethyl ({6-[(3R)-3- methylmorpholin-4-yl]- 2-{1H-pyrrolo[2,3-b]- pyridin-4-yl}pyrimidin- 4-yl}imino)-lambda6-sulfanone
SMILES CCS(=O)(CC)=Nc1cc(nc(n1)-c1ccnc2[nH]ccc12)N1CCOC[C@H]1C
InChI Key
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 411429
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System
US Patent
Board Of Regents, The University Of Texas System
US Patent
Affinity DataIC50: 2nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System
US Patent
Board Of Regents, The University Of Texas System
US Patent
Affinity DataIC50: 2nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System
US Patent
Board Of Regents, The University Of Texas System
US Patent
Affinity DataIC50: 44nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand Info
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System
US Patent
Board Of Regents, The University Of Texas System
US Patent
Affinity DataIC50: 2nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info