BDBM411525 (R)-((2-(2-isopropyl-1H- benzo[d]imidazol-1-yl)- 6-(3-methylmorpholino)- pyrimidin-4-yl)imino)- dimethyl-lambda6-sulfanone::US10392376, Example 76::US10800769, Example 76::US11434233, Example 76

SMILES CC(C)c1nc2ccccc2n1-c1nc(cc(n1)N1CCOC[C@H]1C)N=S(C)(C)=O

InChI Key InChIKey=YPSULNSCVGYXQC-OAHLLOKOSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 411525   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM411525((R)-((2-(2-isopropyl-1H- benzo[d]imidazol-1-yl)- 6...)
Affinity DataIC50:  17nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM411525((R)-((2-(2-isopropyl-1H- benzo[d]imidazol-1-yl)- 6...)
Affinity DataIC50:  17nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM411525((R)-((2-(2-isopropyl-1H- benzo[d]imidazol-1-yl)- 6...)
Affinity DataIC50:  408nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM411525((R)-((2-(2-isopropyl-1H- benzo[d]imidazol-1-yl)- 6...)
Affinity DataIC50:  17nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent