BDBM411565 ((2-(2-Amino-6- chloropyridin-4-yl)-6- ((R)-3-methyl- morpholino)pyrimidin-4- yl)imino)(methyl)- (oxetan-3-yl)-lambda6- sulfanone::US10392376, Example 116::US10800769, Example 116::US11434233, Example 116

SMILES C[C@@H]1COCCN1c1cc(N=S(C)(=O)C2COC2)nc(n1)-c1cc(N)nc(Cl)c1

InChI Key InChIKey=GRJVHVDMPMNUCB-BKVLDKJMSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 411565   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM411565(((2-(2-Amino-6- chloropyridin-4-yl)-6- ((R)-3-meth...)
Affinity DataIC50:  105nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM411565(((2-(2-Amino-6- chloropyridin-4-yl)-6- ((R)-3-meth...)
Affinity DataIC50:  105nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM411565(((2-(2-Amino-6- chloropyridin-4-yl)-6- ((R)-3-meth...)
Affinity DataIC50:  58nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM411565(((2-(2-Amino-6- chloropyridin-4-yl)-6- ((R)-3-meth...)
Affinity DataIC50:  105nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent