BDBM412171 (3S)-2-[(2S)-3,3-dimethyl- 2-[[(2S)-2- (methylamino)propanoyl] amino]butanoyl]-7-[[2- [[(3S)-6-[(4- fluorophenyl)methyl]-3- methyl-1-[2-[(2R,5R)-5- methyl-2-[[(3R)-3- methylmorpholin-4- yl]methyl]piperazin-1- yl]acetyl]-2H-indole-3- carbonyl]amino]acetyl] amino]-N-[(1R)-1,2,3,4- tetrahydronaphthalen-1-yl]- 3,4-dihydro-1H- isoquinoline-3- carboxamide;trihydrochloride::US10398702, Example 10
SMILES CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)CNC(=O)[C@]3(C)CN(C(=O)CN4C[C@@H](C)NC[C@@H]4CN4CCOC[C@H]4C)c4cc(Cc5ccc(F)cc5)ccc34)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C
InChI Key InChIKey=BJHUHNWTABFPGG-JBRJAVIZSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 412171
Affinity DataIC50: 1.26E+3nMAssay Description:For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ...More data for this Ligand-Target Pair
Ligand Info
TargetBaculoviral IAP repeat-containing protein 2 [260-351](Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Hoffmann-La Roche
US Patent
Affinity DataIC50: 2nMAssay Description:For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-...More data for this Ligand-Target Pair
Ligand Info
TargetBaculoviral IAP repeat-containing protein 2 [174-256](Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Hoffmann-La Roche
US Patent
Affinity DataIC50: 1.62E+3nMAssay Description:For the Bir2 assay, 12 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine38 disclosed as SEQ ID NO: 25), corresponding to amino acids 174-256...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2nMAssay Description:For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε...More data for this Ligand-Target Pair
Ligand Info