BDBM412533 US10399972, Example 24::{3,9-difluoro-8-[(1S,4S)-2-oxa-5- azabicyclo[2.2.1]hept-5-yl]-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6-yl}[trans- 4-(propan-2- yloxy)cyclohexyl]methanone

SMILES CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2cc(F)c(cc12)N1C[C@@H]2C[C@H]1CO2

InChI Key InChIKey=CHNWNUVCJSDKKR-FIRPJDEBSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412533   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM412533(US10399972, Example 24 | {3,9-difluoro-8-[(1S,4S)-...)
Affinity DataIC50: <10nMAssay Description:Inhibition of IDH1 RI32C mutant (unknown origin) by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM412533(US10399972, Example 24 | {3,9-difluoro-8-[(1S,4S)-...)
Affinity DataIC50:  5.60nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent