BDBM412743 N-(3-fluoropyridin-4-yl)-2-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::US10399987, Example 8

SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccccn1

InChI Key InChIKey=OFFLEANUVDDEBL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412743   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412743(N-(3-fluoropyridin-4-yl)-2-(pyridin-2-yl)-7H-pyrro...)
Affinity DataIC50:  150nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412743(N-(3-fluoropyridin-4-yl)-2-(pyridin-2-yl)-7H-pyrro...)
Affinity DataIC50:  0.260nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent