BDBM412783 N-(6-{4-[methyl(pyridin-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}pyridin-2-yl)methanesulfonamide::US10399987, Example 48

SMILES CN(c1ccncc1)c1nc(nc2[nH]ccc12)-c1cccc(NS(C)(=O)=O)n1

InChI Key InChIKey=UMWGQZMHOOMNMF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412783   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412783(N-(6-{4-[methyl(pyridin-4-yl)amino]-7H-pyrrolo[2,3...)
Affinity DataIC50: >1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Bristol-Myer Squibb

US Patent
LigandPNGBDBM412783(N-(6-{4-[methyl(pyridin-4-yl)amino]-7H-pyrrolo[2,3...)
Affinity DataIC50:  4.30nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent