BDBM414028 1-methanesulfonyl-3- [(7R)-7-methyl-6-{1H- pyrrolo[2,3-b]pyridin-4- yl}-5H,6H,7H,8H- pyrido[4,3-d]pyrimdin-4- yl]pyrrolidine::US10421765, Example 17::US10745420, Example 17

SMILES C[C@@H]1Cc2ncnc(C3CCN(C3)S(C)(=O)=O)c2CN1c1ccnc2[nH]ccc12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414028   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM414028(1-methanesulfonyl-3- [(7R)-7-methyl-6-{1H- pyrrolo...)
Affinity DataIC50:  936nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM414028(1-methanesulfonyl-3- [(7R)-7-methyl-6-{1H- pyrrolo...)
Affinity DataIC50:  936nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent