BDBM416237 US10442819, Example 381::trans-4-{[8-(tetrahydro-2H- pyran-4-yl)-5,11-dihydro-6H- pyrido[2,3- b][1,5]benzodiazepin-6- yl]carbonyl}-N-[1- (trifluoromethyl)cyclopropyl] cyclohexanamine

SMILES FC(F)(F)C1(CC1)N[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)C1CCOCC1

InChI Key InChIKey=IXQJRECVKZZBPZ-XYWHTSSQSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416237   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416237(US10442819, Example 381 | trans-4-{[8-(tetrahydro-...)
Affinity DataIC50:  15nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent