BDBM416395 ((2R,5S)-5-isopropoxytetrahydro- 2H-pyran-2-yl)(8-((3S,4R)-4- methyltetrahydrofuran-3-yl)-5,11- dihydro-6H-benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)methanone::US10442819, Example 538
SMILES CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)[C@H]1COC[C@@H]1C
InChI Key InChIKey=QJFSVYBHFNAXPN-COFNMNJVSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 416395
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 5nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair