BDBM416396 ((2R,5S)-5-isopropoxytetrahydro- 2H-pyran-2-yl)(8-((3R,4S)-4- methyltetrahydrofuran-3-yl)-5,11- dihydro-6H-benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)methanone::US10442819, Example 539

SMILES CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)[C@@H]1COC[C@H]1C

InChI Key InChIKey=QJFSVYBHFNAXPN-CXEBNRJLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 416396   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM416396(((2R,5S)-5-isopropoxytetrahydro- 2H-pyran-2-yl)(8-...)
Affinity DataIC50:  9nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series. 125 nL of each dilution or DMSO alone is disp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent