BDBM416576 1-isobutyl-3-(2-(2,2,2-trifluoroethoxy)quinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::US10307425, Example 43::US10632122, Example 43

SMILES CC(C)Cn1nc(-c2ccc3nc(OCC(F)(F)F)ccc3c2)c2c(N)ncnc12

InChI Key InChIKey=NTSFCRQMHYOHIV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 416576   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

US Patent
LigandPNGBDBM416576(1-isobutyl-3-(2-(2,2,2-trifluoroethoxy)quinolin-6-...)
Affinity DataIC50:  2nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCAM kinase, CDPK family TgCDPK1(Toxoplasma gondii (strain ATCC 50861 / VEG))
University Of Washington

US Patent
LigandPNGBDBM416576(1-isobutyl-3-(2-(2,2,2-trifluoroethoxy)quinolin-6-...)
Affinity DataIC50:  2nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent