BDBM416712 (2S)-3-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-phenyl-propanamide and (2R)-3-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-phenyl-propanamide::US10323028, Example 45(a)::US10981904, Example 45(a)

SMILES COC[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccccc1

InChI Key InChIKey=JLQVBCYPFNMOEH-SJORKVTESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 416712   

TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM416712((2S)-3-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Affinity DataIC50:  1.60E+3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM416712((2S)-3-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Affinity DataIC50:  1.60E+3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent