BDBM418817 N-methyl-4-({4-[({3- [methyl(methylsulfonyl)amino]pyrazin-2- yl}methyl)amino]-5- (trifluoromethyl)pyrimidin-2- yl}amino)benzamide (317)::US10450297, Example 317::US10450297, Example 318
SMILES CNC(=O)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1
InChI Key InChIKey=FWLMVFUGMHIOAA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 418817
Affinity DataIC50: <0.595nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Affinity DataIC50: 0.630nMAssay Description:Inhibition of FAK (unknown origin) using Fluorescein-Poly GAT as substrate incubated for 30 mins and measured after 60 mins by Lanthascreen assayMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant FAK using poly[Glu:Tyr] (4:1) substrate in presence of 10 mM ATP and [gamma33P]-ATPMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant FAKMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of human Focal adhesion kinaseMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST-FAK catalytic domain region (411-686) (unknown origin) expressed in baculovirus infected Sf9 cells by spectrophotometryMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FAK (unknown origin) incubated for 40 mins by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Guizhou Medical University
Curated by ChEMBL
Guizhou Medical University
Curated by ChEMBL
Affinity DataIC50: 273nMAssay Description:Inhibition of VEGFR-2 (unknown origin) incubated for 40 mins by HTRF assayMore data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Guizhou Medical University
Curated by ChEMBL
Guizhou Medical University
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Inhibition of Pyk2 (unknown origin) measured after 40 mins by HTRFMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Guizhou Medical University
Curated by ChEMBL
Guizhou Medical University
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of TRKA (unknown origin) measured after 40 mins by HTRFMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Guizhou Medical University
Curated by ChEMBL
Guizhou Medical University
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of TRKB (unknown origin) measured after 40 mins by HTRFMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of TRKC (unknown origin) measured after 40 mins by HTRFMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of JAK2 (unknown origin) measured after 40 mins by HTRFMore data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Inhibition of JAK3 (unknown origin) measured after 40 mins by HTRFMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Guizhou Medical University
Curated by ChEMBL
Guizhou Medical University
Curated by ChEMBL
Affinity DataIC50: 129nMAssay Description:Inhibition of TYK2 (unknown origin) measured after 40 mins by HTRFMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Sichuan University-University Of Oxford Huaxi Joint Centre For Gastrointestinal Cancer
Curated by ChEMBL
Affinity DataIC50: <0.5nMAssay Description:Inhibition of recombinant FAK (unknown origin) by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.79nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair