BDBM419982 2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro- 1H-pyrrolo[2,3-c]pyridin-4- yl)-6-(methylsulfonyl)-2H- 1,4-benzoxazin-3(4H)-one::US10472358, Example 48::US10781209, Example 48::US11059821, Example 48::US11702416, Example 48

SMILES Cn1cc(-c2cc(cc3NC(=O)C(CCO)Oc23)S(C)(=O)=O)c2cc[nH]c2c1=O

InChI Key

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 419982   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM419982(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM419982(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM419982(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM419982(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM419982(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM419982(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM419982(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM419982(2-(2-hydroxyethyl)-8-(6- methyl-7-oxo-6,7-dihydro-...)
Affinity DataIC50: <100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent