BDBM420310 2-Methyl-3-[(1-methylethyl)amino]-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-5-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]benzamide::US10478426, Example 2

SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc(NC(C)C)c1C)-c1ccc(nc1)N1CCN(C)CC1

InChI Key InChIKey=BUADPKQHLDXMLK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 420310   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM420310(2-Methyl-3-[(1-methylethyl)amino]-N-[(6-methyl-2-o...)
Affinity DataIC50:  40nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM420310(2-Methyl-3-[(1-methylethyl)amino]-N-[(6-methyl-2-o...)
Affinity DataIC50:  40nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent