BDBM421278 3-(8-Amino-6-(trifluoromethyl)imidazo[1,2- a]pyrazin-3-yl)-N-(4- (hydroxymethyl)bicyclo[2.1.1]hexan-1- yl)benzenesulfonamide::US10479795, Example 394

SMILES Nc1nc(cn2c(cnc12)-c1cccc(c1)S(=O)(=O)NC12CC(CO)(C1)CC2)C(F)(F)F

InChI Key InChIKey=PQJNOEFSYBJECG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 421278   

LigandPNGBDBM421278(3-(8-Amino-6-(trifluoromethyl)imidazo[1,2- a]pyraz...)
Affinity DataIC50: <500nMAssay Description:PI3Kδ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM421278(3-(8-Amino-6-(trifluoromethyl)imidazo[1,2- a]pyraz...)
Affinity DataIC50: <100nMAssay Description:PI3K-γ:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.)....More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent