BDBM4301 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide::CHEMBL296407::Tyrphostin deriv. 40::benzylidenemalononitrile (BMN) deriv. 46

SMILES NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N

InChI Key InChIKey=USOXQZNJFMKTKJ-XVNBXDOJSA-N

Data  1 KI  13 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 4301   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataKi:  3.50E+3nM IC50:  1.00E+4nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory activity against HIV-1 integrase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50:  2.20E+4nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50:  2.20E+4nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDynamin-1(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibitory activity against dynamin1 GTPase expressed in sheep brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50:  6.46E+3nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50: >3.33E+5nMAssay Description:Inhibition of human recombinant Tdp1 assessed as conversion of 14-mer 5'-32P-labeled 3'-phosphotyrosyl DNA substrate N14Y to 14-mer 5'-32P-labeled 3'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50:  4.47E+3nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50:  1.00E+4nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article