BDBM431946 US10576064, Example I-19

SMILES Fc1c(Cl)cccc1[C@H]1[C@H]2[C@H](CCNC2=O)N(CC2CCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12

InChI Key InChIKey=FZWRMSNIZHOASX-UGCAPWQASA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 431946   

TargetE3 ubiquitin-protein ligase Mdm2 [23-127](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM431946(US10576064, Example I-19)
Affinity DataIC50:  240nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent