BDBM432248 3-Hydroxy-N-[1-(3-methoxyphenyl)-1H-pyrazol-3-yl]-N-(1-methylpiperidin-4-::US10577360, Example 111

SMILES COc1cccc(c1)-n1ccc(n1)N(C1CCN(C)CC1)C(=O)c1cccc(O)c1

InChI Key InChIKey=KGYTWKJBVJGHDW-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 432248   

TargetMu-type opioid receptor(Homo sapiens (Human))
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432248(3-Hydroxy-N-[1-(3-methoxyphenyl)-1H-pyrazol-3-yl]-...)
Affinity DataKi: <100nMAssay Description:To investigate binding properties of test compounds to human μ-opioid receptor, transfected CHO-K1 cell membranes and [3H]-DAMGO (Perkin Elmer, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432248(3-Hydroxy-N-[1-(3-methoxyphenyl)-1H-pyrazol-3-yl]-...)
Affinity DataKi: >5.00E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent