BDBM434869 7-[(18S)-19-Phenyl-17-oxa-2,8,9-triazapentacyclo[17.2.2.11,18.16,9.112,16]hexacosa-6(26),7,12::US10577383, Example 29

SMILES Nc1cc(C2CCNC34CCC(CC3)([C@H](C4)Oc3cccc(CCn4cc2cn4)c3)c2ccccc2)c2nn[nH]c2n1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 434869   

TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434869(7-[(18S)-19-Phenyl-17-oxa-2,8,9-triazapentacyclo[1...)
Affinity DataIC50:  50nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434869(7-[(18S)-19-Phenyl-17-oxa-2,8,9-triazapentacyclo[1...)
Affinity DataIC50:  50nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent