BDBM435346 (trans)-2-(3-methyl-1,2,4-oxadiazol-5-yl)- N-((2-(pyrazin-2-ylmethyl)-5-(3- (trifluoromethoxy)phenyl)-1,2,3,4- tetrahydroisoquinolin-8- yl)methyl)cyclopropanecarboxamide (mixture of 2 isomers)::US10568876, Example 107

SMILES Cc1noc(n1)[C@@H]1CC1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc3cnccn3)Cc12

InChI Key InChIKey=SHPXSFFCWGHBQD-WUBHUQEYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435346   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435346((trans)-2-(3-methyl-1,2,4-oxadiazol-5-yl)- N-((2-(...)
Affinity DataIC50:  4.77E+3nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent