BDBM435523 (2R,3S,4R,5R)-5-(4-amino-5-fluoro-7H- pyrrolo[2,3-d]pyrimidin-7-yl)-2-(((2- aminoquinolin-7-yl)oxy)methyl)-3- methyltetrahydrofuran-3,4-diol::US10570140, Example 6::US11078205, Example 6::US11208416, Example 6

SMILES C[C@@]1(O)[C@@H](COc2ccc3ccc(N)nc3c2)O[C@H]([C@@H]1O)n1cc(F)c2c(N)ncnc12

InChI Key InChIKey=XNAPHTQOZUJCQT-GYPMPWGGSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435523   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM435523((2R,3S,4R,5R)-5-(4-amino-5-fluoro-7H- pyrrolo[2,3-...)
Affinity DataIC50:  0.850nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM435523((2R,3S,4R,5R)-5-(4-amino-5-fluoro-7H- pyrrolo[2,3-...)
Affinity DataIC50:  0.850nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM435523((2R,3S,4R,5R)-5-(4-amino-5-fluoro-7H- pyrrolo[2,3-...)
Affinity DataIC50:  0.850nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent