BDBM435702 (2R,3S,4R,5R)-2-((R)-hydroxy(4- (trifluoromethoxy)phenyl)methyl)-3- methyl-5-(4-methyl-7H-pyrrolo[2,3- d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol::US10570140, Example 60::US11078205, Example 60::US11208416, Example 60

SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(OC(F)(F)F)cc2)[C@@](C)(O)[C@H]1O

InChI Key InChIKey=ZSKVLCPSGFORGC-DARIXABFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435702   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM435702((2R,3S,4R,5R)-2-((R)-hydroxy(4- (trifluoromethoxy)...)
Affinity DataIC50:  368nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM435702((2R,3S,4R,5R)-2-((R)-hydroxy(4- (trifluoromethoxy)...)
Affinity DataIC50:  368nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM435702((2R,3S,4R,5R)-2-((R)-hydroxy(4- (trifluoromethoxy)...)
Affinity DataIC50:  368nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent