BDBM435705 (2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimidin-7-yl)-2-((R)-(4- fluoro-3-(trifluoro- methyl)phenyl)(hydroxy)methyl)- 3-methyltetrahydrofuran-3,4-diol::US10570140, Example 63::US11078205, Example 63::US11208416, Example 63

SMILES C[C@]1(O)[C@@H](O)[C@@H](O[C@@H]1[C@H](O)c1ccc(F)c(c1)C(F)(F)F)n1ccc2c(N)ncnc12

InChI Key InChIKey=NOWWVBFXXUUWKN-FOOXYVKASA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435705   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM435705((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM435705((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM435705((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Affinity DataIC50:  3nMAssay Description:Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent