BDBM436099 4-(((3S,4R)-1-((2,4-dichlorophenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)methyl)-2-fluorobenzonitrile::US10590077, Example 1

SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(Cl)cc1Cl

InChI Key InChIKey=QZEQBRBATVPHSA-IFXJQAMLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436099   

TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436099(4-(((3S,4R)-1-((2,4-dichlorophenyl)sulfonyl)-4-hyd...)
Affinity DataIC50:  5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent