BDBM436197 US10590109, Compound 15::US10590109, Compound 20
SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N
InChI Key InChIKey=WMIQOTMTEKRJFD-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 436197
TargetFibroblast growth factor receptor 4 [460-802](Homo sapiens (Human))
Nanjing Innocare Pharma Tech
US Patent
Nanjing Innocare Pharma Tech
US Patent
Affinity DataIC50: 55nMAssay Description:FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1 [308-731](Homo sapiens (Human))
Nanjing Innocare Pharma Tech
US Patent
Nanjing Innocare Pharma Tech
US Patent
Affinity DataIC50: >1.00E+3nMAssay Description:FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4 [460-802](Homo sapiens (Human))
Nanjing Innocare Pharma Tech
US Patent
Nanjing Innocare Pharma Tech
US Patent
Affinity DataIC50: <10nMAssay Description:FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1 [308-731](Homo sapiens (Human))
Nanjing Innocare Pharma Tech
US Patent
Nanjing Innocare Pharma Tech
US Patent
Affinity DataIC50: >1.00E+3nMAssay Description:FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Mus musculus)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 minsMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3 [399-806](Homo sapiens (Human))
Nanjing Innocare Pharma Tech
US Patent
Nanjing Innocare Pharma Tech
US Patent
Affinity DataIC50: >1.00E+3nMAssay Description:FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG channel in presence of dofetilide by competition binding assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Mus musculus)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibition of FGFR4 in mouse BAF3 cells assessed as reduction in cell viability incubated for 2 days by cell proliferation assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2 [400-821](Homo sapiens (Human))
Nanjing Innocare Pharma Tech
US Patent
Nanjing Innocare Pharma Tech
US Patent
Affinity DataIC50: >1.00E+3nMAssay Description:FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...More data for this Ligand-Target Pair