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BDBM4377 2-amino-3-(3,4-dihydroxyphenyl)propanoic acid::DOPA::L-DOPA

SMILES: NC(Cc1ccc(O)c(O)c1)C(O)=O

InChI Key: InChIKey=WTDRDQBEARUVNC-UHFFFAOYSA-N

Data: 6 KI  1 IC50

PDB links: 11 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 4377   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-HT3A Serotonin Receptor


(Mus musculus (house mouse))
BDBM4377
PNG
(2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | DO...)
Show SMILES NC(Cc1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



SRI International

Curated by PDSP Ki Database




NIDA Res Monogr 178: 440-66 (1998)

More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM4377
PNG
(2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | DO...)
Show SMILES NC(Cc1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by PDSP Ki Database




J Pharmacol Exp Ther 282: 181-91 (1997)

More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C)


(Rattus norvegicus (Rat))
BDBM4377
PNG
(2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | DO...)
Show SMILES NC(Cc1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



SRI International

Curated by PDSP Ki Database




NIDA Res Monogr 178: 440-66 (1998)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM4377
PNG
(2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | DO...)
Show SMILES NC(Cc1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



SRI International

Curated by PDSP Ki Database




NIDA Res Monogr 178: 440-66 (1998)

More data for this
Ligand-Target Pair
Dopamine D1 and D2 receptor


(Homo sapiens (Human))
BDBM4377
PNG
(2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | DO...)
Show SMILES NC(Cc1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
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>1.00E+4n/an/an/an/an/an/an/an/a



SRI International

Curated by PDSP Ki Database




NIDA Res Monogr 178: 440-66 (1998)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM4377
PNG
(2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | DO...)
Show SMILES NC(Cc1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



SRI International

Curated by PDSP Ki Database




NIDA Res Monogr 178: 440-66 (1998)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4377
PNG
(2-amino-3-(3,4-dihydroxyphenyl)propanoic acid | DO...)
Show SMILES NC(Cc1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
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Article
PubMed
n/an/a 9.00E+5n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


J Med Chem 32: 2344-52 (1989)

More data for this
Ligand-Target Pair