BDBM441926 US10647694, Example 14

SMILES CCOc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=UPTWBUUDINOIEZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 441926   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Arromax Pharmatech

US Patent
LigandPNGBDBM441926(US10647694, Example 14)
Affinity DataIC50:  5.5nMAssay Description:The in-vitro kinase assay was performed using the HTRF kinEASE TK kit available from Cisbio. The operation steps are indicated in the instructions of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Arromax Pharmatech

US Patent
LigandPNGBDBM441926(US10647694, Example 14)
Affinity DataIC50:  37nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Arromax Pharmatech

US Patent
LigandPNGBDBM441926(US10647694, Example 14)
Affinity DataIC50:  106nMAssay Description:Inhibition of wild-type ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Arromax Pharmatech

US Patent
LigandPNGBDBM441926(US10647694, Example 14)
Affinity DataIC50:  52nMAssay Description:Inhibition of ALK F1174L mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed