BDBM443437 US10654866, Example 4A::US11117902, Example 4B::US11634426, Example 4A

SMILES Oc1ccc2c3[C@H](Oc4c(Cl)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1

InChI Key InChIKey=WPFXKSQRNMAJGV-HHHXNRCGSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 443437   

TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443437(US10654866, Example 4A | US11117902, Example 4B | ...)
Affinity DataKi:  0.340nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443437(US10654866, Example 4A | US11117902, Example 4B | ...)
Affinity DataKi:  2.34nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443437(US10654866, Example 4A | US11117902, Example 4B | ...)
Affinity DataKi:  16.8nMAssay Description:The purpose of the following ER competition binding assays is to determine the affinity of a test compound against ERα (wild type), ERα (Y5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443437(US10654866, Example 4A | US11117902, Example 4B | ...)
Affinity DataKi:  16.8nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443437(US10654866, Example 4A | US11117902, Example 4B | ...)
Affinity DataKi:  55nMAssay Description:Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM443437(US10654866, Example 4A | US11117902, Example 4B | ...)
Affinity DataKi:  55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent