BDBM443500 US10660877, Example 77
SMILES CC(C)c1c([nH]c2ccc(C3CCNCC3)c(F)c12)-c1cc(C)nc(C)c1
InChI Key InChIKey=VCSMIPVBBBTQIR-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 443500
Affinity DataIC50: 0.5nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Affinity DataIC50: 344nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair