BDBM445345 (S)-4-isopropyl-1-methyl-3-(2-(((S)-1-(1-(4-trifluoromethyl)phenyl)-1H-imidazole-4-yl)ethyl)amino)pyrimidin-4-yl)methylimidazolidine-2-one::US10682352, Compound 112::US10682352, Compound 58::US10682352, Compound 84::US10682352, Compound 96

SMILES CC(C)[C@H]1CN(C)C(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)(F)F)n1

InChI Key InChIKey=UXXHPNCKEINKJX-HNAYVOBHSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 445345   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM445345((S)-4-isopropyl-1-methyl-3-(2-(((S)-1-(1-(4-triflu...)
Affinity DataIC50: <100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM445345((S)-4-isopropyl-1-methyl-3-(2-(((S)-1-(1-(4-triflu...)
Affinity DataIC50: <100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM445345((S)-4-isopropyl-1-methyl-3-(2-(((S)-1-(1-(4-triflu...)
Affinity DataIC50: <100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

US Patent
LigandPNGBDBM445345((S)-4-isopropyl-1-methyl-3-(2-(((S)-1-(1-(4-triflu...)
Affinity DataIC50: <100nMAssay Description:Measurements were performed in a reaction volume of 15 uL using 384-well assay plates. Kinase enzyme, inhibitor, ATP and 1 uM peptide substrate were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent